Molecular prognostic signature for predicting breast cancer metastasis, and uses thereof
AssigneeCelera Corporation
InventorsKit LAU, Alice WANG
Life of this patent
Estimating the term…
Abstract
The present invention is based on the discovery of a unique 14-gene molecular prognostic signature that is useful for predicting breast cancer metastasis. In particular, the present invention relates to methods and reagents for detecting and profiling the expression levels of these genes, and methods of using the expression level information in predicting risk of breast cancer metastasis.
Claims20
A method of determining risk associated with tumor metastasis in a breast cancer patient, comprising:
- (a) measuring the expression level of genes comprising CENPA, PKMYT1, MELK, MYBL2, BUB1, RACGAP1, TK1, UBE2S, DC13, RFC4, PRR11, DIAPH3, ORC6L and CCNB1 in estrogen receptor-positive tumor cells of said breast cancer patient, thereby obtaining a metastasis score (MS) based upon the expression levels of said genes;
- and
- (b) determining risk of tumor metastasis for said breast cancer patient by comparing said metastasis score to at least one predefined metastasis score cut off threshold (MS threshold).
A kit comprising reagents for detecting the expression levels of genes comprising CENPA, PKMYT1, MELK, MYBL2, BUB1, RACGAP1, TK1, UBE2S, DC13, RFC4, PRR11, DIAPH3, ORC6L and CCNB1;
- an enzyme;
- and
- a buffer.
A microarray comprising polynucleotides that hybridize to genes comprising CENPA, PKMYT1, MELK, MYBL2, BUB1, RACGAP1, TK1, UBE2S, DC13, RFC4, PRR11, DIAPH3, ORC6L and CCNB1.
Dependencies are inferred from the claim text.