Device and methods for detecting analytes in saliva
AssigneeKoninklijke Philips N.V.
InventorsJeroen Hans NIEUWENHUIS, Ahmed Mohammed Taki JEHANLI, Femke Karina DE THEIJE, Eduard Gerard Marie PELSSERS
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Abstract
The invention provides a device for detecting drugs of abuse or other compounds in saliva. The invention thus provides a device for detecting the presence of one or more analytes in a saliva sample, comprising: (a) One or more pre-treatment regions for specifically or non-specifically removing at least a part of the fraction of the saliva sample interfering with detection of the one or more analytes; and (b) A detection region comprising a biosensor surface, the surface comprising: molecules capable of specifically binding the one or more analytes; or the one or more analytes and/or analyte analogues.
Claims19
A microfluidic device for detecting the presence of one or more analytes in a saliva sample, comprising:
- (a) one or more pre-treatment regions comprising a surface which comprises hydroxyapatite as a first molecule capable of specifically or non-specifically binding to one or more saliva components in the saliva sample interfering with the detection of the one or more analytes for specifically or non-specifically removing at least a part of the fraction of components in the saliva sample interfering with detection of the one or more analytes;
- and
- (b) a detection region comprising a biosensor surface, the biosensor surface comprising:
- second molecules capable of specifically binding the one or more analytes;
- or
- the one or more analytes and/or second molecules which are structurally related to the analyte and bind analyte-specific probes.
A method for detecting the presence of one or more analytes in a saliva sample, comprising the steps of contacting the saliva sample with a device comprising:
- (a) One or more pre-treatment regions comprising a surface which comprises hydroxyapatite as a first molecule capable of specifically or non-specifically binding to one or more saliva components in the saliva sample interfering with the detection of the one or more analytes for specifically or non-specifically removing at least a part of the fraction of components in the saliva sample interfering with detection of the one or more analytes;
- and
- (b) A detection region comprising a biosensor surface, the biosensor surface comprising:
- second molecules capable of specifically binding the one or more analytes;
- or
- the one or more analytes and/or second molecules which are structurally related to the analyte and bind analyte-specific probes.
Dependencies are inferred from the claim text.