Beta 1,4-galactosyltransferases with altered donor and acceptor specificities, compositions and methods of use
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Servic
InventorsPradman K. Qasba, Boopathy Ramakrishnan, Elizabeth Boeggeman
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Abstract
The invention relates generally to beta (1,4)-galactosyltransferase I mutants having altered donor and acceptor specificities, and methods of use thereof. In addition, the invention relates to methods for synthesizing oligosaccharides using the beta (1,4)-galactosyltransferase I mutants and to using the beta (1,4)-galactosyltransferase I mutants to conjugate agents, such as therapeutic agents or diagnostic agents, to acceptor molecules.
Claims9
1-16. (canceled)
A nucleic acid molecule comprising SEQ ID NO:
- 1.
(canceled)
(canceled)
22-137. (canceled)
Dependencies are inferred from the claim text.