Hepatocyte growth factor (hgf) binding proteins
AssigneeAVEO Pharmaceuticals, Inc.
InventorsMay Han, S. Kirk Wright, William M. Winston, JR., Lyne Breault, Jie Lin, Bijan Etemad-Gilbertson, Christine Knuehl, Jeno Gyuris
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Abstract
The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
Claims22
1-100. (canceled)
An isolated nucleic acid comprising a nucleotide sequence encoding an immunoglobulin heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 169, and encoding an immunoglobulin light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 179, wherein the immunoglobulin heavy chain variable region and the immunoglobulin light chain variable region together bind human hepatocyte growth factor (HGF).
A host cell comprising:
- a first expression vector comprising a nucleic acid sequence encoding an immunoglobulin heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 169;
- and
- a second expression vector comprising a nucleic acid sequence encoding an immunoglobulin light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 179;
- wherein the immunoglobulin light chain variable region and the immunoglobulin heavy chain variable region together bind human hepatocyte growth factor (HGF).
An isolated nucleic acid comprising a nucleotide sequence encoding an immunoglobulin heavy chain comprising the amino acid sequence of SEQ ID NO:
- 171, and encoding an immunoglobulin light chain comprising the amino acid sequence of SEQ ID NO:
- 181, wherein the immunoglobulin heavy chain and the immunoglobulin light chain together bind human hepatocyte growth factor (HGF).
A host cell comprising:
- a first expression vector comprising a nucleic acid sequence encoding an immunoglobulin heavy chain comprising the amino acid sequence of SEQ ID NO:
- 171;
- and
- a second expression vector comprising a nucleic acid sequence encoding an immunoglobulin light chain comprising the amino acid sequence of SEQ ID NO:
- 181;
- wherein the immunoglobulin light chain and the immunoglobulin heavy chain together bind human hepatocyte growth factor (HGF).
An isolated nucleic acid comprising a nucleotide sequence encoding an immunoglobulin heavy chain comprising the amino acid sequence of SEQ ID NO:
- 210, and encoding an immunoglobulin light chain comprising the amino acid sequence of SEQ ID NO:
- 181, wherein the immunoglobulin light chain and the immunoglobulin heavy chain together bind human hepatocyte growth factor (HGF).
A host cell comprising:
- a first expression vector comprising a nucleic acid sequence encoding an immunoglobulin heavy chain comprising the amino acid sequence of SEQ ID NO:
- 210;
- and
- a second expression vector comprising a nucleic acid sequence encoding an immunoglobulin light chain comprising the amino acid sequence of SEQ ID NO:
- 181;
- wherein the immunoglobulin light chain and the immunoglobulin heavy chain together bind human hepatocyte growth factor (HGF).
Dependencies are inferred from the claim text.