mTOR Ligands and Polynucleotides Encoding mTOR Ligands
AssigneeIntrexon Corporation
InventorsThomas David REED, Amy H. Aztel
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Abstract
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mTOR activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Claims31
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An isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide heteropolyligand, wherein each of the heteropolyligand monomers is an amino acid sequence at least 90% identical to any one of SEQ ID NOS:
- 24, 25, 31-33, 37-46 and 48-54, wherein Xaa is any amino acid, and wherein said polypeptide heteroligand inhibits mTOR activity.
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Dependencies are inferred from the claim text.