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AssigneeNational University of Ireland Maynooth
InventorsJohn Martin Doyle, Kieran Walshe, Natasha Gordon, Kevin Kavanagh, Lorna Gallagher
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The present invention relates to a method for detecting infections caused by or associated with siderophore-secreting microorganisms and kits and components used therein for carrying out the method. In one aspect the invention relates to a method for detecting siderophores and/or detecting infections caused by or associated with siderophore-secreting microorganisms in a biological sample of a subject, the method comprising providing a solid support having either bound siderophore or a conjugate thereof, or bound anti-siderophore antibody; reacting the bound siderophore or a conjugate thereof, with an anti-siderophore antibody, and a biological sample of a subject; or reacting the bound anti-siderophore antibody with a siderophore or conjugate thereof, and a biological sample of a subject; and detecting and/or quantifying the presence of the siderophore in the biological sample.
A method for detecting siderophores, preferably fusarinine C (FusC) or a derivative thereof, such as triacetylfusarinine C (TAFC), and/or detecting infections caused by or associated with siderophore-secreting microorganisms, preferably an Aspergillus fumigatus infection, more preferably invasive aspergillosis (IA), in a biological sample of a subject, the method comprising:
7-8. (canceled)
An immunogen comprising siderophore, preferably FusC and/or TAFC, covalently coupled to a carrier protein.
15-27. (canceled)
A kit for use in detecting siderophores, preferably fusarinine C (FusC) and derivatives thereof, such as triacetylfusarinine C (TAFC), and/or detecting infections caused by or associated with siderophore-secreting microorganisms, preferably an Aspergillus fumigatus infection, more preferably invasive aspergillosis (IA), in a biological sample of a subject comprising:
Dependencies are inferred from the claim text.