Compositions and methods for diagnosing and treating cancer and neurodegenerative diseases related to beclin-1
AssigneeYeda Research and Development Co. Ltd.
InventorsAdi Kimchi, Einat Zalckvar
Life of this patent
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Abstract
The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a phospho-mimicking residue and uses thereof for treating cancer and neurodegenerative diseases.
Claims13
1-55. (canceled)
A method of determining the level of Beclin-1 phosphorylated at residue Thr 119 in a test sample, comprising determining the level of Beclin-1 that is phosphorylated at position Thr 119 in a test sample using an antibody having specific binding affinity for a human Beclin-1 phosphorylated at residue Thr 119, or an antigen binding fragment thereof.
Dependencies are inferred from the claim text.