Method of diagnosing and treating an aspergillus species-associated condition
AssigneeBoard of Regents of the Nevada System of Higher Education, on Behalf of the Univ. of Nevada, Reno
InventorsDavid Aucoin, Thomas R. Kozel, Sindy Chaves
Life of this patent
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Abstract
Disclosed herein are methods of diagnosing, monitoring and treating an Aspergillus species-associated condition, such as Aspergillus fumigatus (Af)-associated condition, including aspergillosis, such as invasive aspergillosis (IA). Methods for diagnosing and/or monitoring an Aspergillus species-associated condition, such as IA are provided. Also disclosed are point-of-care immunoassays that can be used to diagnose or monitor the efficacy of an Aspergillus-associated condition treatment. These immunoassays can also be used for rapid diagnosis of infection produced by an Aspergillus species, such as Af.
Claims28
A method of diagnosing a subject with an Aspergillus species-associated condition or monitoring the efficacy of a therapy, comprising:
- detecting at least one Aspergillus species-associated molecule in a sample obtained from a subject exhibiting one or more signs or symptoms associated with an Aspergillus species-associated condition or a subject known to be at risk of acquiring an Aspergillus species-associated condition, wherein the at least one Aspergillus species-associated molecule is at least one antigen listed in Table 1, thereby diagnosing the subject with the Aspergillus species-associated condition or determining the efficacy of the therapy.
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A method of monitoring an Aspergillus species-associated condition, comprising:
- detecting at least one Aspergillus species-associated molecule in a sample obtained from a subject exhibiting one or more signs or symptoms associated with an Aspergillus species-associated condition or a subject known to be at risk of acquiring an Aspergillus species-associated condition, wherein the at least one Aspergillus species-associated molecule is at least one antigen listed in Table 1, thereby monitoring the Aspergillus species-associated condition.
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A kit for detecting an Aspergillus species-associated condition, comprising at least one molecule capable of detecting at least one Aspergillus species-associated molecule presented in Table 1 and directions for using the kit to detect an Aspergillus species-associated condition.
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Dependencies are inferred from the claim text.