Murine Astroviruses
AssigneeWashington University
InventorsHerbert W. Virgin, David Wang, Joy Loh, Thad Stappenbeck, Guoyan Zhao, Larissa Thackray, Christine Yokoyama
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Abstract
Novel murine astroviruses, and methods of detecting the viruses are disclosed. Also disclosed are uses of the viruses and infected animals as model systems for discovery and development of vaccines and therapies for diseases caused by or associated with astrovirus infection, including human astrovirus-based diseases.
Claims20
An oligonucleotide consisting of a sequence of from 10 to 70, or about 70 nucleotides, wherein said oligonucleotide hybridizes to a nucleic acid of a murine astrovirus or the complement thereof under high stringency conditions.
A method of detecting presence, absence or quantity of a murine astrovirus in a biological sample, the method comprising:
- providing a sample comprising or suspected of comprising an astrovirus;
- contacting the sample with at least one nucleic acid probe comprising a sequence of at least 10 nucleotides wherein the nucleic acid probe is complementary to a nucleotide sequence that has at least 70% sequence identity with an astrovirus nucleic acid sequence or the complement thereof, under hybridization conditions;
- and
- detecting presence, absence or quantity of a hybrid nucleic acid comprising the probe and the astrovirus nucleic acid.
An oligopeptide consisting of at least 9 amino acid residues up to 60 amino acid residues, or about 60 amino acid residues of a murine astrovirus antigen.
Dependencies are inferred from the claim text.