Composition for preventing and healing osteonecrosis of the jaw
AssigneeMicropure, Inc.
InventorsJames L. Ratcliff, Michael Z. Marder, Robert W. Marder, Jessica K. Ward Dykstra, Elena J. Young, Esmeralda Ann Garcia
Life of this patent
Estimating the term…
Abstract
A composition for preventing and treating all forms of osteonecrosis of the jaw are disclosed. The composition is comprised of 0.005%-2.0% weight/volume (w/v) chlorine dioxide source, such as sodium chlorite, chlorite ion, stabilized chlorine dioxide or similar and may take the form of a paste, gel, rinse, spray, powder, varnish or similar. The prevention and treatment includes the application of the composition in the oral cavity and other body areas affected by osteonecrosis of the jaw.
Claims26
A composition for arresting and healing osteonecrosis of the jaw (ONJ) with a non-invasive procedure, said composition comprising:
- (a) an alcohol free composition for application to ONJ tissues and lesions comprising a solution of a chlorine dioxide source having a concentration in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide;
- (b) said composition having an antimicrobial effect against free-floating microorganisms that are present in lesions and tissues affected by ONJ;
- (c) said composition penetrating, controlling or eliminating biofilm that forms over tissues affected by or susceptible to ONJ;
- (d) said composition producing an antimicrobial effect against microorganisms present in biofilm formed over tissues affected by or susceptible to ONJ;
- and
- (e) said composition non-invasively debriding oral tissue affected by ONJ.
A composition for penetrating, controlling and eliminating the biofilm associated with osteonecrosis of the jaw (ONJ), said composition comprising:
- (a) an alcohol free composition for application to ONJ tissues and lesions comprising a solution of a chlorine dioxide source having a concentration in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide;
- (b) said composition producing an antimicrobial effect against free-floating microorganisms that are present in lesions and tissues affected by ONJ;
- (c) said composition penetrating, controlling or eliminating biofilm that forms over tissues affected by or susceptible to ONJ;
- (d) said composition producing an antimicrobial effect against microorganisms present in biofilm formed over tissues affected by or susceptible to ONJ;
- and
- (e) said composition non-invasively debriding oral tissue affected by ONJ.
A composition for treating and arresting bisphosphonate-related osteonecrosis of the jaw (ONJ), said composition comprising:
- (a) an alcohol free composition for application to ONJ tissues and lesions comprising a solution of a chlorine dioxide source having a concentration in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide;
- (b) said composition producing an antimicrobial effect against free-floating microorganisms that are present in lesions and tissues affected by ONJ;
- (c) said composition penetrating, controlling or eliminating biofilm that forms over tissues affected by or susceptible to ONJ;
- (d) said composition producing an antimicrobial effect against microorganisms present in biofilm formed over tissues affected by or susceptible to ONJ;
- and
- (e) said composition non-invasively debriding oral tissue affected by ONJ.
A composition for preventing osteonecrosis of the jaw, said composition comprising a solution of chlorine dioxide in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide.
A composition for healing osteonecrosis of the jaw, said composition comprising a solution of chlorine dioxide in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide.
A composition for preventing, controlling and eliminating the biofilm associated with osteonecrosis of the jaw, said composition comprising a solution of chlorine dioxide in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide.
A composition for treating and preventing bisphosphonate associated osteonecrosis of the jaw, said composition comprising a solution of chlorine dioxide in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide.
Dependencies are inferred from the claim text.