Multi-particulate pharmaceutical composition
AssigneeSun Pharma Advanced Research Company Ltd.
InventorsYashoraj Rupsinh Zala, Nitin Dharmadhikari, Majed Mohammed Khan, Manisha Nabar
Life of this patent
Estimating the term…
Abstract
A multi-particulate pharmaceutical composition suitable for administration in a sprinkle dosage form said particles being less than 2 mm in diameter and comprising a) inert core particles b) an inner layer surrounding said inert core particles, said layer comprising atorvastatin calcium, methyl methacrylate butyl methacrylate-dimethylaminoethyl methacrylate copolymer and disintegrant and c) an outer taste masking layer surrounding the inner layer, said outer layer comprising methyl methacrylate butyl methacrylate-dimethylaminoethyl methacrylate copolymer.
Claims7
1-9. (canceled)
A multi-particulate pharmaceutical composition suitable for administration in a sprinkle dosage form comprising coated particles wherein the particles comprise:
- a) inert core particles;
- b) an inner layer surrounding said inert core particles, said layer comprising atorvastatin calcium, methyl methacrylate butyl methacrylate-dimethylaminoethyl methacrylate copolymer and disintegrant;
- and
- c) an outer taste masking layer surrounding the inner layer, said outer layer comprising methyl methacrylate butyl methacrylate-dimethylaminoethyl methacrylate copolymer;
- and have a particle size distribution such that at least 95% of the particles fall within a size range from about 0.1 mm to about 2.5 mm.
A process for preparing a multi particulate pharmaceutical composition comprising the steps of
- a) dissolving methyl methacrylate butyl methacrylate-dimethylaminoethyl methacrylate copolymer in an organic solvent;
- b) dispersing atorvastatin calcium in the solution obtained in step a);
- c) loading the dispersion onto inert core particles to form an inner layer;
- and
- d) coating the particles obtained in step c) with a taste masking composition comprising methyl methacrylate butyl methacrylate-dimethylaminoethyl methacrylate copolymer to form particles having a particle size distribution such that at least 95% of the particles fall within a size range from about 0.1 mm to about 2.5 mm.
Dependencies are inferred from the claim text.