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US 2014/0178482 A1Published application
Method of producing virus-like particles of picornavirus using a small-ubiquitin-related modifier fusion protein expression system
AssigneeAcademia Sinica
InventorsTing-Fang Wang, Shu-Mei Liang
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Abstract
A method for producing picornaviral capsid protein complexes (e.g., picornavirus like particles) in E. coli using a small-ubiquitin-related fusion protein expression system and an E. coli strain used in practicing this method. Also disclosed is use of the picornaviral capsid protein complexes like thus prepared for eliciting immune responses.
Claims9
A method of eliciting an immune response against a foot-and-mouth disease virus in a subject, comprising administering to a subject in need thereof an effective amount of a virus-like particle of a foot-and-mouth disease virus.
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