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AssigneePerosphere Inc.
InventorsSasha H. Bakhru, Bryan E. Laulicht, Edith Mathiowitz, Solomon S. Steiner
Estimating the term…
Formulations of a neuroprotective agent for parenteral administration are described herein. The formulation is in the form of a concentrated (supersaturated) solution or a concentrated suspension of microparticles. The suspension medium or the solution solvent carrier may also contain dissolved neuroprotective agent. For the supersaturated solutions, the agent is dissolved at high concentrations of at least about 1% by weight, 5% by weight, 10% by weight, 15% by weight, or 20% by weight in a solvent suitable for parenteral administration. For the concentrated suspension, the microparticles have an effective particle size from about 100 nm to about 5 microns, preferably from about 50 nm to about 3 microns, more preferably from about 10 nm to about 2 microns. The formulations described herein can be used to treat a variety of neurological diseases/disorders and/or neurological injury or trauma.
A pharmaceutical composition comprising a supersaturated solution of a neuroprotective agent or a concentrated suspension of the microparticles of the neuroprotective agent in a pharmaceutically acceptable carrier suitable for parenteral administration,
20-21. (canceled)
Microparticles of a neuroprotective agent, wherein the microparticles have a surface modifying agent adsorbed on the surface thereof, wherein the surface modifying agent is present in an amount of 0.0001 to 90% by weight of the total weight of the surface modifying agent and the neuroprotective agent, wherein the microparticles have an effective particle size of less than about 100 microns, wherein the neuroprotective agent is an anti-convulsant agent and/or anti-epileptic agent.
24-55. (canceled)
A method for preventing further secondary neuronal damage resulting from a neurological disease, disorder, or trauma comprising parenterally administering to a patient an effective amount of a pharmaceutical composition comprising a supersaturated solution of a neuroprotective agent or a concentrated suspension of the microparticles of the neuroprotective agent in a pharmaceutically acceptable carrier suitable for parenteral administration, wherein the neuroprotective agent is an anti-convulsant agent and/or anti-epileptic agent.
Dependencies are inferred from the claim text.