Immuno-Adjuvant Emulsion
AssigneeSanofi Pasteur Limited
InventorsMarie-Francoise Klucker, Francois Dalencon, Patricia Probeck-Quellec
Life of this patent
Estimating the term…
Abstract
The invention relates to an oil-in-water adjuvant emulsion which comprises at least: squalene, an aqueous solvent, a polyoxyethylene alkyl ether nonionic surfactant, a hydrophobic nonionic surfactant, which emulsion is thermoreversible, and wherein 90% of the population by volume of the oil drops has a size less than 200 nm. The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, wherein the oil-in-water emulsion is obtained by means of a temperature-variation phase-inversion process.
Claims27
An oil-in-water emulsion which comprises:
- i) squalene,
- ii) an aqueous solvent,
- iii) a polyoxyethylene alkyl ether hydrophilic nonionic surfactant, and
- iv) a hydrophobic nonionic surfactant,
- wherein the emulsion is thermoreversible and wherein 90% of the population by volume of the oil drops has a size less than 200 nm.
Dependencies are inferred from the claim text.