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US 2014/0178477 A1Published application
Solid preparation
AssigneeNorgine BV
InventorsTomohiro Yoshinari, Yutaka Ebisawa, Hiroshi Suzuki
Life of this patent
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Abstract
The present invention provides a solid preparation formulation containing a poorly water-soluble agent having a low melting point, a saccharide, and a cellulose selected from a crystalline cellulose and a low-substituted hydroxypropylcellulose, in which the saccharide/cellulose weight ratio exceeds 2 and the cellulose content is not less than 5 wt %. This formulation provides a composition that can be produced with direct granulation, yet which delivers stability during production and storage.
Claims13
A solid preparation having the following characteristics 1) to 3):
- 1) containing 2-hexadecyloxy-6-methyl-4H-3, 1-benzoxazin-4-one or a salt thereof, a saccharide, and a cellulose selected from a crystalline cellulose and a low-substituted hydroxypropylcellulose,
- 2) a saccharide/cellulose weight ratio exceeding 2, and
- 3) a cellulose content of not less than 5 wt %.
Dependencies are inferred from the claim text.