Methods of Regulating Glucose Metabolism, and Reagents Related Thereto
AssigneesTrustees of Tufts College, 1149336 Ontario Inc., New England Medical Center Hospitals, Inc.
InventorsWilliam W. Bachovchin, Andrew G. Plaut, Daniel J. Drucker
Life of this patent
Estimating the term…
Abstract
The present invention provides methods and compositions for modification and regulation of glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinemia, obesity, hyperlipidemia, hyperlipoprotein-emia (such as chylomicrons, VLDL and LDL), and to regulate body fat and more generally lipid stores, and, more generally, for the improvement of metabolism disorders, especially those associated with diabetes, obesity and/or atherosclerosis.
Claims31
1-37. (canceled)
A method for modifying glucose metabolism, comprising administering orally to an animal in need thereof a therapeutically effective amount of an inhibitor of dipeptidylpeptidase IV (DPIV) or a pharmaceutically acceptable salt thereof once daily, wherein the inhibitor has a Ki for inhibition of DPIV of 10 nM or less;
- the duration of the therapeutic effect is at least about 24 hours;
- and the inhibitor is administered in an amount sufficient to increase the plasma half-life of glucagon-like peptide 1 (GLP-1) but not sufficient to suppress the immune system of the animal.
Dependencies are inferred from the claim text.