Multi-layered release formulation
AssigneeUniversiteit Gent
InventorsJean Paul Remon, Chris Vervaet
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Abstract
The present invention in general relates to a pharmaceutical dosage form comprising a multi-layered release formulation formed by co-extrusion. Said formulation in particular comprises a core layer comprising at least one polymer selected from polycaprolactone, ethylcellulose, or combinations thereof; and a coat layer comprising at least one (co)polymer selected from the list comprising: polyethylene oxide; polyethylene glycol; Basic Butylated Methacrylate (co)polymer; a (co)polymer of polyvinylcaprolactam, PEG and polyvinylacetate; or combinations thereof.
Claims15
1-15. (canceled)
A solid pharmaceutical dosage form comprising a multi-layered release formulation formed by co-extrusion comprising:
- a core layer comprising at least one polymer selected from the group consisting of polycaprolactone, ethylcellulose, or combinations thereof, and
- a coat layer comprising at least one (co)polymer selected from the group consisting of polyethylene oxide, polyethylene glycol, basic butylated methacrylate (co)polymer, a (co)polymer of polyvinylcaprolactam, polyethylene glycol and polyvinylacetate, or combinations thereof;
- wherein at least one of said layers includes an active ingredient.
A method of preparing a multi-layered release formulation comprising:
- co-extruding a core layer comprising at least one polymer selected from the group consisting of polycaprolactone, ethylcellulose, or combinations thereof;
- and
- a coat layer comprising at least one (co)polymer selected from the group consisting of polyethylene oxide, polyethylene glycol, basic butylated methacrylate (co)polymer, a (co)polymer of polyvinylcaprolactam, polyethylene glycol and polyvinylacetate, or combinations thereof;
- wherein at least one of said layers includes an active ingredient.
Dependencies are inferred from the claim text.