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US 2014/0178455 A1Published application
Gradient Porous Scaffolds
AssigneeUniversity of Connecticut
InventorsSyam P. Nukavarapu, Cato T. Laurencin, Ami R. Amini, Deborah L. Dorcemus
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Abstract
The present invention provides gradient porous scaffolds for bone regeneration and osteochondral defect repair, methods for making such gradient porous scaffolds, and methods for using the gradient porous scaffolds.
Claims17
A gradient porous scaffold, comprising a plurality of biodegradable microspheres that are joined to form a scaffold, wherein the scaffold comprises a porosity gradient along a length of the scaffold.
A method for making a gradient porous scaffold, comprising:
- (a) mixing a plurality o f microspheres with porogen in a desired ratio to produce a mixture, wherein the mixing comprises, mixing the plurality of microspheres with different ratios of porogen to produce a plurality of mixes;
- (ii) combining the plurality of mixes to produce the mixture, such that a ratio of the porogen increases along a length of the mixture;
- (b) sintering the mixture for a suitable time and under suitable conditions to bond adjacent microspheres, producing a sintered mixture;
- and
- (c) leaching porogen from the sintered mixture to produce a gradient porous scaffold.
2 more elements
Dependencies are inferred from the claim text.