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US 2014/0178454 A1Published application
Coating Comprising an Amorphous Primer Layer and a Semi-Crystalline Reservoir Layer
AssigneeAbbott Cardiovascular Systems Inc.
InventorsFlorencia Lim, Mikael O. Trollsas, Syed F.A. Hossainy, Stephen D. Pacetti
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Abstract
The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
Claims20
An implantable device, comprising a coating comprising:
- a reservoir layer comprising a biodegradable semi-crystalline polymer, and
- a primer comprising a biodegradable amorphous polymer;
- wherein the semi-crystalline polymer is selected from semi-crystalline poly(L-lactide-co-glycolide) (PLLA-GA) with the content of L-lactide ranging from about 65 molar % to about 100 molar %, semi-crystalline poly(L-lactide-co-caprolactone) (PLLA-CL) (L-lactide/CL=75/25 or 70/30 by molar), and combinations thereof;
- wherein the amorphous polymer has a miscibility of at least 5% in the semi-crystalline polymer;
- and
- wherein the coating has a degradation or absorption rate that within a period of 6 months after deployment of the implantable device, the coating has a mass loss of about 80% or more.
3 more elements
A method of fabricating an implantable device, comprising
- forming a coating comprising a semi-crystalline reservoir layer that comprises a biodegradable semi-crystalline polymer and an amorphous primer layer that comprises a biodegradable amorphous polymer;
- wherein the semi-crystalline polymer is selected from semi-crystalline poly(L-lactide-co-glycolide) (PLLA-GA) with the content of L-lactide ranging from about 65 molar % to about 100 molar %, semi-crystalline poly(L-lactide-co-caprolactone) (PLLA-CL) (L-lactide/CL=75/25 or 70/30 by molar), and combinations thereof;
- wherein the amorphous polymer has a miscibility of at least 5% in the semi-crystalline polymer;
- and
- wherein the coating has a degradation or absorption rate that within a period of 6 months after deployment of the implantable device, the coating has a mass loss of about 80% or more.
2 more elements
Dependencies are inferred from the claim text.