Anti-Proliferative and Anti-Inflammatory Agent Combination for Treatment of Vascular Disorders with an Implantable Medical Device

A method of treating restenosis or vulnerable plaque of a blood vessel comprising:

• administering to a patient an effective amount of an anti-proliferative agent;
• and
• allowing an effective amount of a steroidal anti-inflammatory agent or a non steroidal anti-inflammatory agent to elute to a vessel from within at least one depot within a body structure of an implantable medical device, wherein the at least one depot has an opening on a surface of the body structure and a depth within the body structure,
• wherein the combination of the anti-proliferative and anti-inflammatory agents is for treatment of restenosis or vulnerable plaque;
• wherein the anti-proliferative agent is everolimus and the steroidal or non-steroidal anti-inflammatory agent is clobetasol,
• and wherein the ratio of the dose of everolimus to the dose of clobetasol is 1:1 to 3:1 on a molar basis.

A method of treating restenosis or vulnerable plaque of a blood vessel comprising:

• implanting a stent in a blood vessel, wherein the stent comprises a scaffolding structure made of a bioabsorbable polymer, wherein an effective amount of a steroidal anti-inflammatory agent or a non steroidal anti-inflammatory agent is mixed or dispersed throughout the scaffolding structure;
• administering to a patient an effective amount of an anti-proliferative agent;
• and
• allowing an effective amount of a steroidal anti-inflammatory agent or a non steroidal anti-inflammatory agent to elute to a vessel from a body structure,
• wherein the combination of the anti-proliferative and anti-inflammatory agents is for treatment of restenosis or vulnerable plaque.