Compositions and Methods for Tissue Repair with Extracellular Matrices
AssigneeThe Regents of the University of California
InventorsKaren Christman, Jessica DeQuach
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Abstract
Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases, such as PAD and CLI, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
Claims20
A method comprising injecting or implanting in a subject with peripheral artery disease an effective amount of a composition comprising decellularized extracellular matrix derived from skeletal muscle tissue.
A method comprising injecting or implanting in a subject with critical limb ischemia an effective amount of a composition comprising decellularized extracellular matrix derived from skeletal muscle tissue.
The method of claim 15, wherein said composition transitions to a gel form after delivery.
A method comprising injecting or implanting in a subject with peripheral artery disease or critical limb ischemia an effective amount of a composition comprising decellularized extracellular matrix derived from a suitable tissue.
Dependencies are inferred from the claim text.