Methods for treating parkinson's disease
AssigneeNuPathe, Inc.
InventorsTerri B. Sebree, Steven J. Siegel
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Abstract
Methods for restoring normal patterns of activity in a subject suffering from Parkinson's Disease are disclosed that include administering an effective steady state concentration of a dopamine modulating compound continuously for a prolonged period of time such that normal patterns of activity are substantially restored in the subject.
Claims29
A method for restoring normal patterns of activity or for increasing on time in a subject suffering from Parkinson's Disease comprising:
- administering an effective amount of a dopamine modulating compound via an implant continuously for at least 15 days such that normal patterns of activity are substantially restored in the subject,
- wherein the implant is formed via co-axial extrusion and comprises:
- a core comprising the dopamine modulating compound and a first biodegradable polymer;
- and
- a sheath, which is disposed about the core, comprising a second biodegradable polymer and optionally said dopamine agonist or a different dopamine agonist.
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A method for the treatment of Parkinson's Disease in a subject in need thereof comprising, administering a continuous delivery of ropinirole for at least 15 days via an implant, in combination with L-Dopa, wherein on time is increased and off time is decreased,
- wherein the implant is formed via co-axial extrusion and comprises:
- a core comprising the dopamine modulating compound and a first biodegradable polymer;
- and
- a sheath, which is disposed about the core, comprising a second biodegradable polymer and optionally said dopamine agonist or a different dopamine agonist.
Dependencies are inferred from the claim text.