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US 2014/0178440 A1Published application
Transmucosal drug delivery devices for use in chronic pain relief
AssigneeBiodelivery Sciences Interntional, Inc.
InventorsAndrew Finn, Niraj Vasisht
Life of this patent
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Abstract
Provided herein are methods for treating chronic pain by administering low doses of buprenorphine twice daily (or once daily) via a transmucosal drug delivery device. The methods and devices efficiently treat chronic pain without significant side effects.
Claims20
A method of treating chronic pain, the method comprising:
- administering to a subject in need thereof a mucoadhesive bioerodable drug delivery device, wherein
- the device is administered once or twice daily, wherein the device comprises about 100 μg to about 0.9 mg buprenorphine;
- and
- the device provides steady-state Cmax of plasma buprenorphine concentration in a range between about 0.1 and about 1.2 ng/mL, such that the subject is treated for chronic pain;
- wherein the subject is an opioid-experienced subject.
2 more elements
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A method of treating a subject with moderate to severe chronic low back pain, comprising:
- administering to the subject twice daily a mucoadhesive bioerodable drug delivery device to an oral mucosal surface of the subject, the device comprising:
- a bioerodable mucoadhesive layer comprising an effective amount of buprenorphine disposed in a buffered polymeric diffusion environment, wherein the polymeric diffusion environment is a buffered environment having a pH of between about 4 and about 6;
- wherein the total daily dose of buprenorphine administered to the subject is effective for treating moderate to severe chronic low back pain;
- wherein the subject is an opioid-experienced subject.
1 more element
A method of treating a subject with neuropathic pain, the method comprising:
- administering to the subject twice daily a mucoadhesive bioerodable drug delivery device to an oral mucosal surface of the subject, the device comprising:
- a bioerodable mucoadhesive layer comprising an effective amount of buprenorphine disposed in a buffered polymeric diffusion environment, wherein the polymeric diffusion environment is a buffered environment having a pH of between about 4 and about 6;
- such that the subject is treated for neuropathic pain;
- wherein the subject is an opioid-experienced subject.
1 more element
A method of treating a subject with osteoarthritic pain, comprising:
- administering to the subject twice daily a mucoadhesive bioerodable drug delivery device to an oral mucosal surface of the subject, the device comprising:
- a bioerodable mucoadhesive layer comprising an effective amount of buprenorphine disposed in a buffered polymeric diffusion environment, wherein the polymeric diffusion environment is a buffered environment having a pH of between about 4 and about 6;
- such that the subject is treated for osteoarthritic pain;
- wherein the subject is an opioid-experienced subject.
1 more element
Dependencies are inferred from the claim text.