Leptospira with increased antigenic mass
OwnerEdwin Kets, Christian Theodoor Gerardus Smits +1inventors
InventorsEdwin Kets, Christian Theodoor Gerardus Smits, Henriette Adriaanse
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Abstract
The antigenic mass of Leptospira cultures can be significantly increased, independent from any increase in biomass, by supplementing Leptospira cultures with a specific fatty acid: linoleic acid. This provides advantages in the production Leptospira antigens. Also this enables the production of improved Leptospirosis vaccines, that are safer and more effective.
Claims7
A method for increasing the antigenic mass of a Leptospira culture, the method comprising the step of supplementing said Leptospira culture with linoleic acid.
A method for producing a vaccine against Leptospirosis, said method comprising the steps of:
- a. proliferating a Leptospira culture in an in vitro system,
- b. supplementing said Leptospira culture with linoleic acid,
- c. inactivating and harvesting said supplemented Leptospira culture, and
- d. admixing the inactivated Leptospira culture with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.