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US 2014/0178432 A1Published application
Production of dense bodies (db) from hcmv-infected cells
AssigneeAiCuris GmbH & Co. KG
InventorsPeter Lischka, Christian Sinzger
Life of this patent
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Abstract
The invention relates to the production of dense bodies (DB) and to a pharmaceutical composition containing DB.
Claims20
1-8. (canceled)
A method for preparing dense bodies, comprising
- (1) preparing biological cells that are infected with human cytomegalovirus (HCMV) in a medium, and
- (2) incubating the infected biological cells with one of the following substances (A), (B), (C) or (D):
- substance (A), which is (4S)-{8-fluoro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)-phenyl]-3,4-dihydro-4-quinazolinyl}acetic acid;
- substance (B), which is N-{1-methyl-2-[(4-(5-methyl-pyridin-2-yl)-piperazin-1-yl)carbonyl]-1H-imidazol-4-yl}-N′-[4-(trifluoromethoxy)phenyl]urea;
- substance (C), which is 1-[6-fluoro-8-methoxy-3-({[2-methyl-4-(trifluoromethoxy)benzyl]amino}carbonyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylic acid;
- or
- substance (D), which is N-{3-[({4-[5-(6-aminopyridin-2yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)amino]-5-fluorophenyl}-1-cyanocyclopropane carboxamide.
4 more elements
Dependencies are inferred from the claim text.