Vaccines Including Antigen From Four Strains of Influenza Virus
AssigneeNovartis AG
InventorTheodore Tsai
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Abstract
Vaccines of the invention include at least four influenza virus strains. In some embodiments, the vaccines are produced in cell culture rather than in eggs. In some embodiments, the vaccines include an adjuvant. In some embodiments, the vaccines are not split or whole virion vaccines, but are live or purified glycoprotein vaccines. In some embodiments, the vaccines contain substantially the same mass of hemagglutinin (HA) for each of the influenza virus strains. In some embodiments, the four strains will include two influenza A virus strains and two influenza B virus strains (‘A-A-B-B’). In other embodiments, the four strains will include three influenza A virus strains and one influenza B virus strain (‘A-A-A-B’).
Claims16
1-39. (canceled)
A vaccine comprising antigens from at least four strains of influenza virus, wherein the four strains consist of a H1 influenza A virus strain, a H3 influenza A virus strain and a first and a second influenza B virus strain, wherein the first influenza B virus strain comprises a B/Victoria/2/87-like hemagglutinin and the second influenza B virus strain comprises a B/Yamagata/16/88-like hemagglutinin;
- and wherein both the first and the second influenza B virus strains comprise a B/Yamagata/16/88-like neuraminidase or a B/Victoria/2/87-like neuraminidase.
Dependencies are inferred from the claim text.