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US 2014/0178425 A1Published application
Compositions for immunising against staphylococcus aureus
AssigneeNovartis AG
InventorsFabio BAGNOLI, Massimiliano BIAGINI, Luigi FIASCHI, Guido GRANDI, Ravi Pratap Narayan MISHRA, Nathalie NORAIS, Maria SCARSELLI
Life of this patent
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Abstract
An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunisation. These polypeptides may optionally be used in combination with S. aureus saccharides.
Claims22
An immunogenic composition comprising a combination of antigens, said combination comprising an hla antigen and one or more antigens selected from the group consisting of:
- (1) a sta006 antigen;
- (2) a sta011 antigen;
- (3) a esxA antigen;
- (4) a esxB antigen;
- (5) a ebpS antigen;
- (6) a efb antigen;
- (7) a emp antigen;
- (8) a esaC antigen;
- (9) a coA antigen;
- (10) a eap antigen;
- (11) a FnBA antigen;
- (12) a FnBB antigen;
- (13) a ebhA antigen;
- (14) a hlgB antigen;
- (15) a hlgC antigen;
- (16) a isdA antigen;
- (17) a isdB antigen;
- (18) a isdC antigen;
- (19) a isdG antigen;
- (20) a isdH antigen;
- (21) a isdl antigen;
- (22) a lukD antigen;
- (23) a lukE antigen;
- (24) a lukF antigen;
- (25) a lukS antigen;
- (26) a nuc antigen;
- (27) a sasA antigen;
- (28) a sasB antigen;
- (29) a sasC antigen;
- (30) a sasD antigen;
- (31) a sasF antigen;
- (32) a sdrC antigen;
- (33) a sdrD antigen;
- (34) a sdrE2 antigen;
- (35) a spa antigen;
- (36) a clfA antigen;
- (37) a clfB antigen;
- (38) a sta001 antigen;
- (39) a sta002 antigen;
- (40) a sta003 antigen;
- (41) a sta004 antigen;
- (42) a sta005 antigen;
- (43) a sta007 antigen;
- (44) a sta008 antigen;
- (45) a sta009 antigen;
- (46) a sta010 antigen;
- (47) a sta012 antigen;
- (48) a sta013 antigen;
- (49) a sta014 antigen;
- (50) a sta015 antigen;
- (51) a sta016 antigen;
- (52) a sta017 antigen;
- (53) a sta018 antigen;
- (54) a sta019 antigen;
- (55) a sta020 antigen;
- (56) a sta021 antigen;
- (57) a sta022 antigen;
- (58) a sta023 antigen;
- (59) a sta024 antigen;
- (60) a sta025 antigen;
- (61) a sta026 antigen;
- (62) a sta027 antigen;
- (63) a sta028 antigen;
- (64) a sta029 antigen;
- (65) a sta030 antigen;
- (66) a sta031 antigen;
- (67) a sta032 antigen;
- (68) a sta033 antigen;
- (69) a sta034 antigen;
- (70) a sta035 antigen;
- (71) a sta036 antigen;
- (72) a sta037 antigen;
- (73) a sta038 antigen;
- (74) a sta039 antigen;
- (75) a sta040 antigen;
- (76) a sta041 antigen;
- (77) a sta042 antigen;
- (78) a sta043 antigen;
- (79) a sta044 antigen;
- (80) a sta045 antigen;
- (81) a sta046 antigen;
- (82) a sta047 antigen;
- (83) a sta048 antigen;
- (84) a sta049 antigen;
- (85) a sta050 antigen;
- (86) a sta051 antigen;
- (87) a sta052 antigen;
- (88) a sta053 antigen;
- (89) a sta054 antigen;
- (90) a sta055 antigen;
- (91) a sta056 antigen;
- (92) a sta057 antigen;
- (93) a sta058 antigen;
- (94) a sta059 antigen;
- (95) a sta060 antigen;
- (96) a sta061 antigen;
- (97) a sta062 antigen;
- (98) a sta063 antigen;
- (99) a sta064 antigen;
- (100) a sta065 antigen;
- (101) a sta066 antigen;
- (102) a sta067 antigen;
- (103) a sta068 antigen;
- (104) a sta069 antigen;
- (105) a sta070 antigen;
- (106) a sta071 antigen;
- (107) a sta072 antigen;
- (108) a sta073 antigen;
- (109) a sta074 antigen;
- (110) a sta075 antigen;
- (111) a sta076 antigen;
- (112) a sta077 antigen;
- (113) a sta078 antigen;
- (114) a sta079 antigen;
- (115) a sta080 antigen;
- (116) a sta082 antigen;
- (117) a sta083 antigen;
- (118) a sta084 antigen;
- (119) a sta085 antigen;
- (120) a sta086 antigen;
- (121) a sta087 antigen;
- (122) a sta088 antigen;
- (123) a sta089 antigen;
- (124) a sta090 antigen;
- (125) a sta091 antigen;
- (126) a sta092 antigen;
- (127) a sta093 antigen;
- (128) a sta094 antigen;
- (129) a sta095 antigen;
- (130) a sta096 antigen;
- (131) a sta097 antigen;
- (132) a sta098 antigen;
- (133) a sta099 antigen;
- (134) a sta100 antigen;
- (135) a sta101 antigen;
- (136) a sta102 antigen;
- (137) a sta103 antigen;
- (138) a sta104 antigen;
- (139) a sta105 antigen;
- (140) a sta106 antigen;
- (141) a sta107 antigen;
- (142) a sta108 antigen;
- (143) a sta109 antigen;
- (144) a sta110 antigen;
- (145) a sta111 antigen;
- (146) a sta112 antigen;
- (147) a sta113 antigen;
- (148) a sta114 antigen;
- (149) a sta115 antigen;
- (150) a sta116 antigen;
- (151) a sta117 antigen;
- (152) a sta118 antigen;
- (153) a sta119 antigen;
- (154) a sta120 antigen;
- (155) a NW—6 antigen;
- (156) a NW—9 antigen;
- (157) a NW—10 antigen;
- (158) a NW—7 antigen;
- (159) a NW—8 antigen;
- (160) a NW—2 antigen;
- (161) a NW—1 antigen;
- (162) a sta081 antigen;
- and (163) a NW—5 antigen.
160 more elements
A polypeptide of formula NH2-A-{-X-L-}n-B-COOH, wherein:
- X is an amino acid sequence of a staphylococcal antigen, selected from the group consisting of S. aureus antigens sta006, sta011, esxA, esxB, hla, clfA, clfB, coA, eap, ebhA, ebpS, efb, emp, esaC, FnBA, FnBB, hlgB, hgC, isdA, isdB, isdC, isdG, isdH, isdI, lukD, lukE, lukF, lukS, nuc, sasA, sasB, sasC, sasD, sasF, sdrC, sdrD, sdrE2, spa, sta001, sta002, sta003, sta004, sta005, sta007, sta008, sta009, sta010, sta012, sta013, sta014, sta015, sta016, sta017, sta018, sta019, sta020, sta021, sta022, sta023, sta024, sta025, sta026, sta027, sta028, sta029, sta030, sta031, sta032, sta033, sta034, sta035, sta036, sta037, sta038, sta039, sta040, sta041, sta042, sta043, sta044, sta045, sta046, sta047, sta048, sta049, sta050, sta051, sta052, sta053, sta054, sta055, sta056, sta057, sta058, sta059, sta060, sta061, sta062, sta063, sta064, sta065, sta066, sta067, sta068, sta069, sta070, sta071, sta072, sta073, sta074, sta075, sta076, sta077, sta078, sta079, sta080, sta081, sta082, sta083, sta084, sta085, sta086, sta087, sta088, sta089, sta090, sta091, sta092, sta093, sta094, sta095, sta096, sta097, sta098, sta099, sta100, sta101, sta102, sta103, sta104, sta105, sta106, sta107, sta108, sta109, sta110, sta111, sta112, sta113, sta114, sta115, sta116, sta117, sta118, NW—6, NW—9, NW—10, NW—7, NW—8, NW—2, NW—1, and NW—5;
- L is an optional linker amino acid sequence;
- A is an optional N-terminal amino acid sequence;
- B is an optional C-terminal amino acid sequence;
- and
- n is an integer of 2 or more.
3 more elements
A polypeptide comprising an amino acid sequence (a) having 80% or more identity to SEQ ID NO:
- 151;
- and/or (b) comprising a fragment of at least 7 consecutive amino acids from amino acids 1-97 of SEQ ID NO:
- 151 and at least 7 consecutive amino acids from amino acids 104-207 of SEQ ID NO:
- 151, wherein the polypeptide can elicit antibodies which recognise both the wild-type staphylococcal protein comprising SEQ ID NO:
- 10 and the wild-type staphylococcal protein comprising SEQ ID NO:
- 11.
3 more elements
A polypeptide comprising amino acid sequence having 80% or more identity to an amino acid sequence selected from SEQ ID NOs:
- 151, 152, 168, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 220, 221, 222, 223, 224, 237, 238, 241.
A polypeptide comprising an amino acid sequence selected from SEQ ID NOs:
- 151, 152, 168, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 220, 221, 222, 223, 224, 237, 238, 241, 242, 243, 244, 245.
A polypeptide comprising:
- (a) a first sequence having 90% or more identity to SEQ ID NO:
- 218;
- and (b) a second sequence having 90% or more identity to SEQ ID NO:
- 219, wherein the first and second sequences are either directly joined or are joined by an intervening amino acid sequence having fewer than 10 amino acids.
1 more element
Dependencies are inferred from the claim text.