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US 2014/0178420 A1Published application
Treatment of Inflammation, Autoimmune, and Neurodegenerative Disorders with Immunosuppressive Tat Derivative Polypeptides
AssigneePIN Pharma, Inc.
InventorsJoshua Goldberg, Colin Bier, Christoph Hotz-Behofsits, Sophie Hanscom
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Abstract
The present specification provides immunosuppressive Tat derivative polypeptides, compositions, and methods of using such polypeptides and compositions to treat an autoimmune disease, an inflammation-associated disease and/or a neurodegenerative disease.
Claims23
An immunosuppressive trans-activator of transcription (Tat) derivative polypeptide comprising an amino acid sequence comprising the following domains in the indicated order:
- a transcription factor (TF) domain comprising a sequence from an immunosuppressive human immunodeficiency virus (HIV), SIV Tat protein, hairless or an artificial immunosuppressive sequence;
- a cysteine-rich region from lentiviral Tat or a defensin molecule;
- and
- a C-terminal region from a lentiviral Tat protein.
1 more element
Dependencies are inferred from the claim text.