Methods and Compositions for Treating Conditions of the Eye
AssigneeMassachusetts Eye and Ear Infirmary
InventorsEvangelos S. Gragoudas, Vasiliki Poulaki, Joan W. Miller
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Abstract
Provided are methods and compositions for treating ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of, for example, a photodynamic therapy (PDT)-based approach can be enhanced by combining the PDT with an anti-FasL factor, for example, an anti-FasL neutralizing antibody.
Claims17
1-16. (canceled)
A method for reducing photoreceptor cell death associated with a photodynamic-therapy-based method that uses a photosensitizer to treat unwanted choroidal neovasculature in a mammal, the method comprising
- administering to an eye of the mammal an amount of an anti-FasL factor sufficient to reduce photoreceptor cell death associated with photodynamic therapy relative to photodynamic therapy without the anti-FasL factor,
- wherein the anti-FasL factor is selected from the group consisting of an anti-FasL antibody, an anti-Fas antibody, decoy receptor 3, and a decoy receptor 3 analog.
Dependencies are inferred from the claim text.