Anti-il-23 antibodies
AssigneeBoehringer Ingelheim International GmbH
InventorsGerald Henry NABOZNY, Annette Bettina GALLER, Patrick GARIDEL, William Troy LOGING, Steven John PADULA, Torsten SCHULTZ-FADEMRECHT, Elaine Ee-Ling WANG
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Abstract
The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies, pharmaceutical compositions and therapeutic and diagnostic methods and compositions for using the same.
Claims28
A pharmaceutical composition comprising an antibody, wherein said pharmaceutical composition comprises:
- a) 1 to 40 mg/ml of said antibody and further comprises 5 to 50 mM succinate buffer and 50 to 200 mM sodium chloride, wherein the pH of said pharmaceutical composition is in the range of pH 6.0 to 7.0;
- or
- b) 70 to 100 mg/ml of said antibody and further comprises 100 to 300 mM sorbitol, wherein the pH of said pharmaceutical composition is in the range of pH 5.5 to 6.5.
A method for treating a disease comprising administering to a subject in need thereof an effective amount of an anti-IL-23p19 antibody or antigen-binding fragment thereof and a pharmaceutically acceptable carrier, wherein the antibody or antigen-binding fragment thereof comprises:
- a) a light chain variable region comprising the amino acid sequence of SEQ ID NO:19 (CDR1-L);
- the amino acid sequence of SEQ ID NO:20 (CDR2-L);
- and the amino acid sequence of SEQ ID NO:21 (CDR3-L);
- and
- b) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 63, 66, 67 or 68 (CDR1-H);
- the amino acid sequence of SEQ ID NO:64 (CDR2-H);
- and the amino acid sequence of SEQ ID NO:65 (CDR3-H),
- wherein the disease is:
- i) plaque psoriasis, chronic plaque psoriasis or moderate to severe chronic plaque psoriasis;
- or
- ii) palmar pustular psoriasis, guttate psoriasis, inverse psoriasis, pustular psoriasis or erythodermic psoriasis;
- or
- iii) non-radiographic axial spondyloarthritis or peripheral spondyloarthritis;
- or
- iv) discoid lupus, malaria, malignant melanoma, aplastic anaemia, Huntington's Disease, palmoplantar pustulosis, IgA nephritis, ANCA-Associated Vasculitis, scleritis or sepsis.
Dependencies are inferred from the claim text.