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AssigneesInstitut Pasteur, Centre National De La Recherche Scientifique, Facultad De Medicina, Universidad De La Republica, Instituto De Investigaciones Siol. Clem. Estasle
InventorsLuis BARBEITO, Mariana Pehar, Patricia Cassina, Pedro M. Alzari
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The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.
(canceled)
A method for treating a disease or condition mediated by a neurotrophin that has been nitrated comprising administering a binder that binds to the nitrated neurotrophin, but that does not bind to the not nitrated neurotrophin, in an amount sufficient to reduce the severity of said disease.
A method comprising actively immunizing a subject with a modified neurotrophin or an immunogenic fragment thereof, wherein said active immunization reduces apoptosis of motor neurons and/or the outgrowth of neurite in said subject.
A method for treating a disease or condition where stimulation and/or induction of motor neuron apoptosis and/or of neurite outgrowth is desired, comprising administering a modified neurotrophin to a subject in need thereof.
A method for detecting a disease or condition involving motor neuron apoptosis and/or neurite outgrowth in a mammal, comprising:
An antibody or other binder for a nitrated neurotrophin that does not bind to the not nitrated neurotrophin.
A composition comprising an isolated nitrated neurotrophin or an isolated immunogenic nitrated fragment of a nitrated neurotrophin.
Dependencies are inferred from the claim text.