Retrograde transport peptide and use of same for delivery to central nervous system
AssigneeUniversity of Washington
InventorsSuzie H. Pun, Drew L. Sellers, Jamie M. Bergen, Philip J. Horner
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Abstract
Transport peptides, alone or attached to a cargo moiety, are capable of targeted axonal import into the spinal cord and other structures of the central nervous system. The transport peptides can be used to deliver therapeutic agents and other molecules of interest from the periphery to the central nervous system, providing a means to detect, treat or prevent neurodegenerative diseases, stroke, chronic pain and other conditions via minimally invasive techniques of administration.
Claims18
A recombinant or synthetic transport peptide, or polynucleotide encoding same, or a derivative thereof, wherein the peptide has the amino acid sequence QSQSQMR (SEQ ID NO:
- 1), ASGAQAR (SEQ ID NO:
- 2), PF, or TSTAPHLRLRLTSR (SEQ ID NO:
- 7). 2.
Dependencies are inferred from the claim text.