Sgp130/fc dimers
AssigneeConaris Research Institute AG
InventorsGeorg H. Wätzig, Dirk Seegert
Life of this patent
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Abstract
Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein the hinge region of the Fc domain is modified resulting in advantageous properties of the dimer. In a particularly preferred embodiment, the hinge region comprises the amino acid sequence motif Ala234-Glu235-Gly236-Ala237. Moreover, a pharmaceutical composition containing said dimer and various medical uses are described.
Claims14
1-17. (canceled)
A method of treating a subject, comprising administering to a subject an effective amount of a pharmaceutical composition comprising a polypeptide dimer capable of inhibiting activity of an agonistic IL-6/sIL-6R complex and comprising two monomers, wherein each of the monomers comprises an extracellular domain of a gp130 molecule fused to an Fc domain of an IgG1 protein, and wherein the Fc domain comprises a hinge region comprising the amino acid sequence of SEQ ID NO:1.
Dependencies are inferred from the claim text.