Antibody-like proteins for therapeutic and diagnostic use
AssigneeThe Trustees of the University pf Pennsylvania
InventorsMark I. Greene, Hongtao Zhang
Life of this patent
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Abstract
Disclosed herein are recombinant protein scaffolds for use in producing antigen-binding proteins. Related antigen-binding proteins are also provided herein. In addition, nucleic acids encoding such recombinant protein scaffolds and antigen-binding proteins are also described. Vectors and cells useful for expression of the described proteins are also provided, as are methods of use.
Claims22
A recombinant antigen-binding protein, comprising an S22 antigen-specific peptide and a CH2 region of an antibody.
A recombinant antigen-binding protein comprising the protein scaffold of SEQ ID NO:
- 14, 16, 17, 18, 19, or 20.
19-21. (canceled)
The method of claim 19, wherein said disease is cancer, wherein said cancer is resistant to treatment with a HER2-specific antibody or and EGFR-specific antibody.
24-26. (canceled)
Dependencies are inferred from the claim text.