Anti-angiogenesis therapy for the treatment of ovarian cancer
AssigneeGenentech, Inc.
InventorsJakob Dupont, Cornelia Irl, Amreen Husain, Mika A. Sovak, Jing Yi, Hoa Nguyen
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Abstract
This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer using an anti-VEGF antibody, preferably in combination with one or more additional anti-tumor therapeutic agents for the treatment of ovarian cancer.
Claims44
A method of treating a patient diagnosed with ovarian cancer, comprising subjecting the patient to a treatment regimen combining a chemotherapy with the administration of an effective amount of an anti-VEGF antibody followed by anti-VEGF maintenance therapy, wherein the chemotherapy of the treatment regimen comprises administration of at least one chemotherapeutic agent, and wherein the treatment regimen effectively extends the progression free survival of the patient.
A kit for treating previously untreated ovarian cancer in a human patient comprising a package comprising an anti-VEGF antibody composition and instructions for using the anti-VEGF antibody composition in combination with taxane therapy and carboplatin followed by anti-VEGF maintenance therapy, wherein the instructions recite that the progression free survival for patients receiving taxane therapy and carboplatin therapy and bevacizumab is 14.1 months with a hazard ratio of 0.717 (p-value<0.0001).
A method of instructing a human subject with ovarian cancer, the method comprising providing instructions to receive ovarian cancer treatment with an anti-VEGF antibody concurrent with chemotherapy followed by anti-VEGF maintenance therapy so as to increase progression free survival of the subject.
A promotional method, comprising promoting administration of an anti-VEGF antibody concurrent with chemotherapy followed by anti-VEGF maintenance therapy for treatment of ovarian cancer in a human subject so as to increase progression free survival of the subject.
A business method, comprising marketing an anti-VEGF antibody therapy concurrent with chemotherapy followed by anti-VEGF maintenance therapy for treatment of ovarian cancer in a human subject so as to increase progression free survival of the subject.
A kit for treating previously untreated ovarian cancer in a human patient comprising a package comprising an anti-VEGF antibody composition and instructions for using the anti-VEGF antibody composition in combination with paclitaxel and carboplatin followed by anti-VEGF maintenance therapy, wherein the instructions recite that the progression free survival for patients receiving paclitaxel, carboplatin and anti-VEGF antibody is 18.3 months with a hazard ratio of 0.79.
Dependencies are inferred from the claim text.