Methods and compositions for treating diseases targeting maba
AssigneeCelera Corporation
InventorsCharles E. BIRSE, Bruno DOMON, Steve RUBEN, Candy LEE
Life of this patent
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Abstract
Methods and compositions for detecting and treating a disease, particularly cancer, associated with differential expression of Maba in disease cells compared to healthy cells. Also provided are antagonists or agonists of Maba, and methods for screening agents that modulate the Maba level or activity in vivo or in vitro.
Claims20
An isolated Maba protein comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:1-7.
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:
- a) SEQ ID NOS:8-14;
- b) nucleotide sequences that encode a Maba protein comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:1-7;
- and
- c) nucleotide sequences that are completely complementary to the nucleotide sequences of a) or b).
A method of diagnosing, prognosing, or determining risk of cancer in a subject, the method comprising detecting at least one molecule in a sample, wherein the presence or abundance of the molecule is indicative of cancer, and wherein the molecule is selected from the group consisting of:
- a) Maba proteins comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:1-7;
- b) antibodies that selectively bind to the Maba protein of a);
- c) nucleic acid molecules comprising a nucleotide sequence selected from the group consisting of SEQ ID NOS:8-14 and nucleotide sequences that encode the Maba protein of a);
- and
- d) nucleic acid molecules comprising a nucleotide sequence that is completely complementary to the nucleic acid molecule of c).
Dependencies are inferred from the claim text.