Compositions and Methods for Treating Celiac Sprue Disease
AssigneeUniversity of Washington through its Center for Commercialization
InventorsJustin Siegel, David Baker, Sydney Rin Anna Gordon, Ingrid Swanson Pultz, Elizabeth Joy Stanley, Sarah Jane Wolf
Life of this patent
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Abstract
The invention provides compositions and methods for treating celiac sprue.
Claims20
A polypeptide comprising an amino acid sequence at least 75% identical to an amino acid sequence according to SEQ ID NO:35, wherein
- (a) the polypeptide degrades a PQPQLP (SEQ ID NO:34) peptide at pH 4;
- (b) residue 278 is Ser, residue 78 is Glu, and residue 82 is Asp;
- and
- (c) the polypeptide comprises an amino acid change from SEQ ID NO:
- 67 at one or more residues selected from the group consisting of 73, 102, 103, 104, 130, 165, 168, 169, 172, and 179.
A polypeptide comprising an amino acid sequence at least 75% identical to an amino acid sequence according to SEQ ID NO:1, wherein
- (a) the polypeptide degrades a PQPQLP (SEQ ID NO:34) peptide at pH 4;
- (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp;
- and
- (c) the polypeptide comprises an amino acid change from SEQ ID NO:
- 33 at one or more residues selected from the group consisting of 119, 262, 291, 292, 293, 319, 354, 357, 358, 361, and 368.
A polypeptide comprising an amino acid sequence according to SEQ ID NO:1, wherein the polypeptide comprises at least one amino acid change from SEQ ID NO:
- 33.
A polypeptide comprising an amino acid sequence according to SEQ ID NO:35, wherein the polypeptide comprises at least one amino acid change from SEQ ID NO:
- 67.
Dependencies are inferred from the claim text.