Cycloalkyl-Substituted Imidazole Derivative

A compound of general formula (I):

• or a pharmacologically acceptable salt thereof, wherein:
• A is a C3 to C12 cycloalkyl group which may be substituted with one to three identical or different groups selected from a fluoro group, a hydroxy group, a C1 to C6 alkyl group, a C1 to C6 alkoxy group, an aryloxy group, and a heterocyclyloxy group;
• R1, R2, and R3 are independently selected from hydrogen, a fluoro group, and a C1 to C6 alkyl group;
• R4 is hydrogen or a prodrug group;
• and
• Y is selected from:
• —CH2—CHR5—CH2—NHR6, wherein R5 is hydrogen, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group, and R6 is hydrogen or a prodrug group;
• —O—CHR7—CH2—NHR8, wherein R7 is hydrogen, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group, and R8 is hydrogen or a prodrug group;
• and
• wherein R9 is hydrogen or a prodrug group, and * is the position for substitution.

A compound of general formula (I-1a):

• or a pharmacologically acceptable salt thereof, wherein:
• A is selected from a cyclobutyl group, a cyclohexyl group, a cycloheptyl group, a bicyclo[3.1.0]hexyl group, a bicyclo[2.2.1]heptyl group, and an adamantyl group, each of which may be substituted with one to three identical or different groups selected from a hydroxy group, a methyl group, and an ethyl group;
• R4 is selected from:
• hydrogen;
• a C1 to C6 alkyl group which may be substituted with one to three identical or different groups selected from a C2 to C6 alkanoyloxy group, a (C3 to C6 cycloalkyl)carbonyloxy group, and an aryl group;
• and
• a heterocyclylalkyl group which may be substituted with one to three identical or different groups selected from an oxo group and a C1 to C6 alkyl group;
• R5 is selected from hydrogen, a C1 to C6 alkyl group, and a C1 to C6 alkoxy group;
• and
• R6 is selected from:
• hydrogen;
• a C1 to C6 alkanoyl group which may be substituted with one to three identical or different groups selected from an amino group, a halogeno group, a hydroxy group, a carboxy group, a carbamoyl group, a C1 to C6 alkoxy group, an aryl group, and a heterocyclyl group;
• a (C1 to C6 alkoxy)carbonyl group which may be substituted with one to three identical or different groups selected from a C1 to C6 alkyl group, a C2 to C6 alkanoyloxy group, a (C3 to C6 cycloalkyl)carbonyloxy group, and an aryl group;
• and
• a heterocyclylalkyloxycarbonyl group which may be substituted with one to three identical or different groups selected from an oxo group and a C1 to C6 alkyl group.

A compound of general formula (A):

• or a salt thereof, wherein:
• Q is selected from —COOR, a hydroxymethyl group, and a formyl group;
• and
• R is a C1 to C6 alkyl group.