Acrylamide hydrogels for tissue engineering
AssigneeEmpire Technology Development LLC
InventorsWilliam B. Carlson, Gregory D. Phelan
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Abstract
Disclosed are acrylamide hydrogels prepared from derivatives of (tetrahydropyranyl)methyl- and (tetrahydrofuranyl)methyl-acrylamide, methods of making the same, and methods of wound healing or tissue generation with acrylamide hydrogels.
Claims30
A hydrogel comprising a polyacrylamide wherein the polyacrylamide comprises one or more repeating units derived from the compound of Formula I:
- and stereoisomers thereof, wherein
- Y is —C(H)(R3)— or —C(H)(R3)—C(H)(R4)—;
- R1, R2, R3, and R4 are independently an —OH, a protected hydroxyl group, or a group of Formula II:
- provided that not more than one of R1, R2, R3, and R4 is a group of Formula II;
- and
- R5, R6, R7 and R8 are independently selected from hydrogen and a substituted or unsubstituted alkyl group.
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A method of making a hydrogel comprising:
- polymerizing one or more compounds of Formula I or stereoisomers thereof in an aqueous solution to form the hydrogel, wherein Formula I is
- and
- Y is —C(H)(R3)— or —C(H)(R3)—C(H)(R4)—;
- R1, R2, R3, and R4 are independently an —OH, a protected hydroxyl group, or a group of Formula II:
- provided that not more than one of R1, R2, R3, and R4 is a group of Formula II;
- and
- R5, R6, R7 and R8 are independently selected from the group consisting of hydrogen and a substituted or unsubstituted alkyl group.
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A non-woven fibrous mat of electrospun polyacrylamide wherein the polyacrylamide comprises one or more repeating units derived from the compound of Formula I:
- and stereoisomers thereof, wherein
- Y is —C(H)(R3)— or —C(H)(R3)—C(H)(R4)—;
- R1, R2, R3, and R4 are independently an —OH, a protected hydroxyl group, or a group of Formula II:
- provided that not more than one of R1, R2, R3, and R4 is a group of Formula II;
- and
- R5, R6, R7 and R8 are independently selected from the group consisting of hydrogen and a substituted or unsubstituted alkyl group.
Dependencies are inferred from the claim text.