Supports and methods for promoting integration of cartilage tissue explants
OwnerJian Q. Yao, Hali Wanginventors
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Abstract
The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.
Claims18
1-20. (canceled)
A method of making expanded cartilage tissue, the method comprising:
- a) placing a plurality of cartilage tissue pieces on a solid support at an inter-piece distance of 1 mm or less, wherein each cartilage tissue piece has an initial volume of less than 1 mm3;
- and
- b) culturing the plurality of cartilage tissue pieces on the solid support for a time and under conditions sufficient for each cartilage tissue piece to attain an expanded volume of at least 1 mm3.
A method of making expanded cartilage tissue, the method comprising culturing a plurality of cartilage tissue pieces on a solid support, wherein each cartilage tissue piece has an initial volume of less than 1 mm3, for a time and under conditions sufficient for each tissue piece to attain an expanded volume of at least 1 mm3.
Dependencies are inferred from the claim text.