Variants of the tnf superfamily and uses thereof
AssigneesInstitució Catalana De Recerca I Estudis AvançAts (Icrea), Fundacio Privada Centre De Regulacio Genomica (CRG)
InventorsLuis Serrano Pubul, Albert Martinus Van Der Sloot, Jan Paul Medema, Fiona Clare Kimberley
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Abstract
Described are novel variants of APRIL that modulate signaling via receptor-specific agonist activity, and nucleic acids encoding these variant proteins. Further described is the use of these novel proteins in the treatment of APRIL-associated disorders, in particular, pathologies of the immune system and oncological disorders.
Claims14
A peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, and a fragment thereof corresponding to amino acid residues 104-250 or amino acid residues 105-250 of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, or SEQ ID NO:12.
A peptide comprising amino acid residues 104-250 or amino acid residues 105-250 of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, or SEQ ID NO:12.
Dependencies are inferred from the claim text.