Antimicrobial Ophthalmic Devices
AssigneeCooperVision International Holding Company, LP
InventorsCarol Ann Morris, Andrew Luk, Inna Maltseva, Arthur Back, Victoria Rogers, Kathleen Khong, Yun Zhang, Ying Ye, Peter Zhu
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Abstract
Antimicrobial ophthalmic devices such as contact lenses, ocular inserts, ocular bandages, and intraocular lenses comprise a hydrogel and an antimicrobially-effective amount of epsilon polylysine non-covalently attached to the hydrogel.
Claims27
An unworn antimicrobial contact lens immersed in a packaging solution and sealed in a package, said contact lens comprising a hydrogel and an antimicrobially-effective amount of epsilon polylysine (εPLL) non-covalently attached to the hydrogel.
A method of manufacturing an unworn antimicrobial contact lens, said method comprising:
- polymerizing a monomer mixture to provide a lens-shaped polymerization product;
- optionally hydrating the polymerization product to form a hydrogel;
- immersing the polymerization product or hydrogel in a package containing a packaging solution;
- sealing the package;
- and optionally sterilizing the sealed package by autoclave, wherein an antimicrobially effective amount of εPLL is non-covalently attached to the hydrogel.
A method of manufacturing a packaged antimicrobial hydrogel contact lens including the step of bringing a lens-shaped polymerization product or a hydrogel contact lens into contact with a packaging solution that comprises εPLL.
Dependencies are inferred from the claim text.