Skin treatments containing pyrroloquinoline quinone (pqq) esters and methods of preparation and use thereof
AssigneeUS Cosmeceutechs, LLC
InventorsJoseph Abernathy Lewis, II, Joseph C. DiNardo
Life of this patent
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Abstract
The present invention relates to cosmetic or dermatological compositions containing PQQ or its esters, methods of treating or promoting skin changes by topical application of these compositions, and methods of synthesis of PQQ esters. The PQQ ester-containing compositions of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the PQQ esters of the present invention have an antioxidant effect that is useful in treating a skin change.
Claims27
A cosmetic or dermatological compositions comprising:
- (1) a compound of formula (I):
- optionally as a salt, wherein R1, R2, and R3 Simultaneousiy or separately represent a lower C1-6 alkyl, lower C2-6 alkenyl, lower C2-6 alkynyl, C4-12-ar-C1-6-alkyl, C4-12 arC4-12-aryl, phenyl, or hydrogen, and
- (ii) superoxide dismutase, catalase, catalase promoter, or a combination thereof,
- wherein the composition is provided in a form of a cream, lotion, solution, serum, anhydrous preparation, emulsion, microemulsion multiple emulsion gel, solid stick, ointment, dry powder, spray, or aerosol.
A method of reducing or eliminating a detrimental skin change, or promoting a positive skin change, the method comprising:
- topically administering to a subject in need thereof a composition comprising a therapeutically effective amount of a compound of formula (I).
- optionally as a salt,
- wherein R1, R2, and R3 simultaneously or separately represent a lower C1-6 alkyl, lower C2-6 alkenyl, lower C2-6 alkynyl, C4-12-ar-C1-6-alkyl, C4-12-ar-C4-12-aryl, phenyl, or hydrogen.
A method of promoting growth of extracellular matrix molecules in skin, the method comprising:
- topically administering to a subject in need thereof a composition comprising a therapeutically effective amount of a compound of formula (I):
- optionally as a salt,
- wherein R1, R2, and R3 simultaneously or separately represent a lower C1-6 alkyl, lower C2-6 alkenyl, lower C2-6 alkynyl, C4-12-ar-C1-6-alkyl C4-12-ar-C4-12-aryl, phenyl, or hydrogen.
27-29. (canceled)
Dependencies are inferred from the claim text.