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AssigneeKabushiki Kaisha Yakult Honsha
InventorsTakekazu Okumura, Tomohiko Terai, Masumi Nakao, Kimiyuki Kaneko, Masahiko Ito, Kouji Miyazaki, Kazuaki Yamaji, Kaoru Tochiya, Nobuhiro Hanada, Susumu Imai, Yoshiaki Nomura, Shunsuke Baba
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Provided is a novel lactic acid bacterium strain which is capable of suppressing production of volatile sulfur compounds by oral bacteria, has no cariogenicity and no causative role in infective endocarditis, and is safe in an oral cavity, and provided is an agent for preventing, improving and/or treating oral diseases and discomforts by use of the bacterial strain. An agent for preventing and/or treating an oral disease, containing, as an active ingredient, at least one lactic acid bacterium selected from Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri, and Streptococcus mitis and having all of the following properties (1) to (6): (1) having no ability to produce a volatile sulfur compound (VSC); (2) having no ability to produce water-insoluble glucan; (3) having adhesiveness to a tooth surface and/or an oral cell; (4) having a growth inhibitory effect on a bad breath-causing bacterium and/or a periodontal pathogen; (5) having no causative role in infective endocarditis; and (6) having no cariogenicity.
An agent for preventing and/or treating an oral disease, the agent comprising, as an active ingredient, at least one lactic acid bacterium selected from the group consisting of Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri, and Streptococcus mitis and having all of the following properties (1) to (6):
An agent for preventing and/or improving bad breath, the agent comprising, as an active ingredient, at least one lactic acid bacterium selected from the group consisting of Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri, and Streptococcus mitis and having all of the following properties (1) to (6):
A lactic acid bacterium designated as Lactobacillus crispatus YIT 12319 and deposited under FERM BP-11500, a lactic acid bacterium designated as Lactobacillus fermentum YIT 12320 and deposited under FERM BP-11501, a lactic acid bacterium designated as Lactobacillus gasseri YIT 12321 and deposited under FERM BP-11502, or a lactic acid bacterium designated as Streptococcus mitis YIT 12322 and deposited under FERM BP-11503.
10-19. (canceled)
A method for preventing and/or treating an oral disease, the method comprising administering to a subject in need thereof an effective amount of at least one lactic acid bacterium selected from the group consisting of Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri, and Streptococcus mitis and having all of the following properties (1) to (6):
A method for preventing and/or improving bad breath, the method comprising administering to a subject in need thereof an effective amount of at least one lactic acid bacterium selected from the group consisting of Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri, and Streptococcus mitis and having all of the following properties (1) to (6):
A primer or probe specific to Lactobacillus crispatus YIT 12319 (FERM BP-11500), comprising a base sequence selected from SEQ ID NOs:
A primer pair specific to Lactobacillus crispatus YIT 12319 (FERM BP-11500) comprising a base sequence selected from the group consisting of
Dependencies are inferred from the claim text.