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AssigneeInstitut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsWilliam Rostene, Christophe Baudouin, David Godefroy, Alexandre Denoyer
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The present invention concerns a method for inducing an increase in the intraocular pressure in an animal, said method comprising ocular administration of a solution comprising benzalkonium chloride (BAK). The present invention further relates to an animal having ocular hypertension, said animal being obtained by the method according to the invention. Said animal provides a convenient animal model for better understanding of the patho-physiological mechanisms involved in ocular hypertension and glaucoma. The present invention also relates to the use of said animal for screening a compound for therapeutic use against ocular hypertension or glaucoma, and/or for assessing potential side-effects of treatment of ocular hypertension and glaucoma.
A method for inducing an increase in intraocular pressure in an animal, said method comprising a step of ocularly administering a solution comprising benzalkonium chloride (BAK) to said animal.
An animal having ocular hypertension, said animal being obtained by
(canceled)
A method for screening a compound for therapeutic use against ocular hypertension or glaucoma, comprising
A method for assessing potential side-effects of a compound for therapeutic use against ocular hypertension and glaucoma, comprising
Dependencies are inferred from the claim text.