Integrin targeted synthetic ligands for diagnostic and therapeutic applications

A compound of formula (III)

• wherein
• n is 1 or 2;
• p is an integer between 1 and 5;
• OR4 and R5 together constitute the sequence Asp-Gly-Arg;
• R6 is a biologically active moiety selected from the group consisting of a radiotherapeutically or diagnostically effective molecule, a phospholipid or lipid moiety, and a biotin or an avidin residue;
• and
• L is a group (i) —CONH—, (ii) —NHCONH—, (iii) —HCSNH—,
• or is a divalent linking moiety comprising two of the groups (i), (ii), (iii), (iv), and/or (v) as terminal groups;
• or the compound of formula (III) is selected from the group consisting of salts, individual enantiomers, individual diastereoisomers, and racemic mixtures of the compound of formula (III) in whatever proportion.