Methods and compositions for detection of cancer
AssigneeCase Western Reserve University
InventorSusann Brady-Kalnay
Life of this patent
Estimating the term…
Abstract
A molecular probe for use in detection of cancer cells expressing an Ig superfamily cell adhesion molecule that binds in a homophilic fashion in a subject includes a targeting agent that specifically binds to and/or complexes with a proteolytically cleaved extracellular fragment of the Ig superfamily cell adhesion molecule.
Claims26
1-41. (canceled)
A method comprising:
- administering to a subject a molecular probe that includes a targeting agent that binds to proteolytically cleaved extracellular fragments of Ig superfamily cell adhesion molecules in the cancer cell microenvironment in the subject.
The method of 42, the molecular probe administered to the subject defining a tumor margin of the cancer cells in the subject.
A method comprising:
- administering to a subject a molecular probe that includes a targeting agent that binds to proteolytically cleaved extracellular fragments of Ig superfamily cell adhesion molecules expressed in the cancer cell microenvironment in the subject;
- and
- detecting in the subject the molecular probe bound to the proteolytically cleaved extracellular fragment of the cell adhesion molecule to provide the location and/or distribution of the cancer cells in the subject.
The method of 53, the molecular probe administered to the subject defining a tumor margin of the cancer cells in the subject.
Dependencies are inferred from the claim text.