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US 2014/0178298 A1Published application
Methods for tumor diagnosis and therapy
AssigneePresident and Fellows of Harvard College
InventorsAmin I. Kassis, Ravi S. Harapanhalli
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Abstract
The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is produced within a specific site (e.g., tumor) at concentrations that are higher than that in normal tissues. Alternatively, the enzyme is conjugated to a targeting moiety such as an antibody or a receptor-binding molecule.
Claims20
A method for the enzyme-mediated, site-specific, in-vivo localization of water-insoluble molecules within a tumor, which comprises:
- the administration of a water-soluble prodrug molecule to an animal;
- said prodrug being a substrate to said enzyme and hydrolyzed by said enzyme molecules present within the tumor, said hydrolysis forming a water-insoluble drug precipitate molecule, wherein said precipitate is trapped within the tumor.
Dependencies are inferred from the claim text.