Tumor-targeted nanodelivery systems to improve early mri detection of cancer
AssigneeGeorgetown University
InventorsEsther H. CHANG, Kathleen F. Pirollo
Life of this patent
Estimating the term…
Abstract
The present invention is in the fields of drug delivery, cancer treatment and diagnosis and pharmaceuticals. This invention provides a method of making antibody- or antibody fragment-targeted immunoliposomes for the systemic delivery of molecules to treat and image diseases, including cancerous tumors. The invention also provides immunoliposomes and compositions, as well as methods of imaging various tissues. The liposome complexes are useful for encapsulation of imaging agents, for example, for use in magnetic resonance imaging. The specificity of the delivery system is derived from the targeting antibodies or antibody fragments.
Claims16
A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome complex comprising:
- (a) preparing an antibody or antibody fragment;
- (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome, wherein said antibody or antibody fragment is not chemically conjugated to said cationic liposome;
- and
- (c) mixing said cationic immunoliposome with an imaging agent at a ratio in the range of about 1.0:10 to about 1.0:35 (mg imaging agent:μg liposome) to form said antibody- or antibody fragment-targeted-cationic immunoliposome complex.
Dependencies are inferred from the claim text.