Methods for imaging bone precursor cells using dual-labeled imaging agents to detect mmp-9 positive cells
AssigneeBaylor College of Medicine
InventorsElizabeth A. Davis, Alan R. Davis, Eva M. Sevick-Muraca, Sunkuk Kwon
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Abstract
The present invention includes embodiments for methods and compositions that identify the presence of or risk for developing heterotopic ossification, particularly prior to mineralization of the bone. In particular embodiments, MMP-9 and/or MMP-2 agents comprising dual imaging moieties are used to identify patterns of MMP-9 and/or MMP-2 localization, respectively, that is then predictive of heterotopic ossification.
Claims13
A method of identifying a site of heterotopic bone formation in an individual or identifying a site at risk of developing heterotopic bone formation in an individual, comprising the step of providing to a localized site in the individual a MMP-9 and/or MMP-2 targeting agent, said agent comprising a first and a second imaging moiety.
Dependencies are inferred from the claim text.